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In another study, male F rats were treated with three intraperitoneal injections of 3-methyl-. Based on the examine of Yeung et al.
Thyroid glands from all surviving F 0 parents were examined microscopically, and brain measurements had been carried out on all uncovered F 1 pups and those F 1 pups chosen for behavioural testing. There have been no important sex differences. In females, a higher proportion was excreted as sulfate conjugate, whereas males excreted the next proportion of a diconjugate each sulfate and glucuronide groups. From these data, the authors concluded that male rats have a better capacity for glucuronidation than females.

Other pores and skin results have been hyperplasia, hyperkeratosis, irritation, and sebaceous gland hyperplasia, whereas there were no systemic therapy-related lesions. With resorcinol, a number of initiation—promotion research with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group have been treated with two subcutaneous injections of. In a study performed by Hasegawa et al.
Determination of resorcinol conjugates in the h urine samples after 14 days of steady product treatment showed that a maximal 23 mg 2. Assuming a body weight of 64 kg IPCS, gives an publicity estimate of 0. In a report based mostly on shopper analysis data Gans, , underneath cheap maximum-use situations i.
There isn't any guideline study on toxicity for aquatic crops available. As only one concentration was tested, the research cannot be used within the danger evaluation. There are a number of studies obtainable on acute toxicity to totally different fish species.
One factor growing potential poisonous results is the application of resorcinol to injured pores and skin Cassano et al. Surviving F 0 parental and F 1 following selection rats underwent full gross necropsy following the breeding interval seven F 0 males per group , following completion of weaning of F 1 pups F zero females , following scheduled necropsy of F 0 females remaining seven F 0 males per group , on PND 28 F 1 uncovered pups , or on PND 30 or 70 F 1 pups selected for behavioural testing.

In in vitro human pores and skin research, resorcinol was evaluated from a consultant hair dye formulation that contained 0. However, it ought to be thought of that acned skin could also be broken due either to scratching or to the blemishes themselves.

• In addition, male rats have greater circulating ranges of TSH than females.





• British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat.





• There is not any indication as as to if the teratogenic results have been endocrine mediated or not EC, c.





• Sacrificed animals showed brown-dyed abdomen partitions and filling of abdomen and small intestine with a darkish-brown to orange substance.





• Assuming a body weight of 64 kg IPCS, offers an exposure estimate of 0.





• Flaked resorcinol triggered no perceptible to moderate irritation intact skin or no perceptible necrosis abraded pores and skin.





• Animals have been maintained for several months with periodic sacrifices Flickinger, The animals have been then examined weekly for 10 additional weeks.

Apart from one optimistic single case-study Vilaplana et al. In these instances, the examined focus of resorcinol was 0. The knowledge are summarized in Table 8. Data in regards to the totally different job categories were not supplied.
In , medical examinations see above and thyroid assessments had been carried out with of presumably energetic plant staff men and 33 girls. Flaked resorcinol brought on no perceptible to moderate irritation intact skin or no perceptible necrosis abraded pores and skin.
Hence, an improved biodegradation price ends in decreased dangers for the setting. Regarding the effects of resorcinol on aquatic species, the toxicity data set consists of quite a lot of species from different trophic levels. Results from exams with different aquatic species from totally different trophic ranges can be found for the acute toxicity of resorcinol to aquatic organisms.

A focus of 0. These substances were discovered to be potent inhibitors of thyroid peroxidase or I organification. Resorcinol in addition to 2- and 5-methylresorcinol had been reported to be At an iodide concentration of 0.

Fifty per cent of survivors had been sacrificed 1 week later, and blood and urine samples were taken. Resorcinol showed a focus-dependent enhance in labelling index [ 3 H]thymidine , acanthosis, and papillomatosis. After utility of an ointment containing To examine the goitrogenic activity of resorcinol, feminine Wistar rats were treated twice daily for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.
For the benthic and terrestrial compartments, the out there toxicity knowledge cannot be considered enough for a quantitative danger characterization. However, these compartments are less relevant for resorcinol, because of marginal releases and emissions to these compartments as well as a really low potential for adsorption of resorcinol to organic matter.