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<br />Animals that died confirmed hyperaemia and distension of abdomen and intestine, while there have been no gross lesions at necropsy in survivors Flickinger, In another research with CFY rats. Most of the research are of adequate quality and acceptable for danger characterization purposes.<br /><br /><h2></h2><br />Although thyroid effects are a significant finish-level in each human case-studies and animal studies, there is a lack of consistency in the leads to the animal studies. Resorcinol triggered no opposed effects in a number of replica and developmental toxicity studies in rats and rabbits. Resorcinol is not thought-about to be genotoxic.<br /><br />Especially in rats, lengthy-term perturbations of the pituitary—thyroid axis caused by xenobiotics or physiological alterations e. For the thyroid, a non-statistically important increase in TSH levels was reported for interim males, however not at scheduled necropsy. In high-dosed females, T 3 levels have been elevated, while there was no impact on T 3 or T four ranges in males.<br /><br /><h1></h1><br /><br /><ul><br />  <br />  <br />  <br /> <li>One factor increasing potential toxic effects is the appliance of resorcinol to injured skin.</li><br />  <br />  <br />  <br /> <li>Based on the examine of Yeung et al.</li><br />  <br />  <br />  <br /> <li>For the benthic and terrestrial compartments, the obtainable toxicity knowledge can't be considered sufficient for a quantitative risk characterization.</li><br />  <br />  <br />  <br /> <li>These figures agree properly with the above exposure estimate primarily based on the Yeung et al.</li><br />  <br />  <br />  <br /> <li>Assuming a physique weight of sixty four kg IPCS, gives an publicity estimate of 0.</li><br />  <br />  <br />  <br /> <li>However, owing to missing correlating histopathological adjustments within the three levels of the mind examined and within the absence of a dose—response relationship, different indicators of developmental delay, or other modifications in CNS operate, these results weren't thought of as conclusive proof of a change in CNS perform.</li><br />  <br /> <br /> <br /></ul><br />A concentration of 0. These substances were found to be potent inhibitors of thyroid peroxidase or I organification. Resorcinol as well as 2- and 5-methylresorcinol have been reported to be At an iodide focus of 0.<br /><br /><h5></h5><br />The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled skin areas confirmed slight erythema and extreme dryness. Mean knowledge for 3 donors and sixteen replicates point out a plateau in receptor fluid focus between 24 and 48 h, as mirrored by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.<br />These figures agree properly with the above exposure estimate based on the Yeung et al.<br /><br />In each species, there have been no antagonistic effects on ultimate imply body weights, haematology, or medical chemistry parameters, and no chemical-associated gross or microscopic lesions were noticed. In another study, rats have been uncovered to zero or zero. No thyroid hormone measurements have been performed.

Revision as of 19:08, 28 March 2020


Animals that died confirmed hyperaemia and distension of abdomen and intestine, while there have been no gross lesions at necropsy in survivors Flickinger, In another research with CFY rats. Most of the research are of adequate quality and acceptable for danger characterization purposes.


Although thyroid effects are a significant finish-level in each human case-studies and animal studies, there is a lack of consistency in the leads to the animal studies. Resorcinol triggered no opposed effects in a number of replica and developmental toxicity studies in rats and rabbits. Resorcinol is not thought-about to be genotoxic.

Especially in rats, lengthy-term perturbations of the pituitary—thyroid axis caused by xenobiotics or physiological alterations e. For the thyroid, a non-statistically important increase in TSH levels was reported for interim males, however not at scheduled necropsy. In high-dosed females, T 3 levels have been elevated, while there was no impact on T 3 or T four ranges in males.







  • One factor increasing potential toxic effects is the appliance of resorcinol to injured skin.




  • Based on the examine of Yeung et al.




  • For the benthic and terrestrial compartments, the obtainable toxicity knowledge can't be considered sufficient for a quantitative risk characterization.




  • These figures agree properly with the above exposure estimate primarily based on the Yeung et al.




  • Assuming a physique weight of sixty four kg IPCS, gives an publicity estimate of 0.




  • However, owing to missing correlating histopathological adjustments within the three levels of the mind examined and within the absence of a dose—response relationship, different indicators of developmental delay, or other modifications in CNS operate, these results weren't thought of as conclusive proof of a change in CNS perform.





A concentration of 0. These substances were found to be potent inhibitors of thyroid peroxidase or I organification. Resorcinol as well as 2- and 5-methylresorcinol have been reported to be At an iodide focus of 0.


The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled skin areas confirmed slight erythema and extreme dryness. Mean knowledge for 3 donors and sixteen replicates point out a plateau in receptor fluid focus between 24 and 48 h, as mirrored by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.
These figures agree properly with the above exposure estimate based on the Yeung et al.

In each species, there have been no antagonistic effects on ultimate imply body weights, haematology, or medical chemistry parameters, and no chemical-associated gross or microscopic lesions were noticed. In another study, rats have been uncovered to zero or zero. No thyroid hormone measurements have been performed.